Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCNO | P22674 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19754131 | 0.90 | HPGD (0.45) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL4748541 | 0.84 | SMN1; SMN2 (0.65) | ALDH1A1HPGDHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL4746341 | 0.84 | ALDH1A1 (0.48) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL18949733 | 0.80 | ALDH1A1 (0.55) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL31500060 | 0.78 | SMN1; SMN2 (0.69) | ALDH1A1HPGDSMN1; SMN2MAPTTDP1 | |
| SCHEMBL7506607 | 0.77 | SMN1; SMN2 (0.59) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL6096779 | 0.76 | NPC1 (0.40) | SMN1; SMN2MAPTTHRBKDM4ENPC1 | |
| SCHEMBL27780413 | 0.75 | ALDH1A1 (0.51) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL3683961 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 | |
| SCHEMBL16019533 | 0.74 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010005851-A1 | COMBINATION THERAPY FOR TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2010-01-14 | — | — | WO | claimed |
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | claimed |
| WO-2010005851-A1 | COMBINATION THERAPY FOR TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2010-01-14 | — | — | WO | disclosed |
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008121861-A2 | PYRAZOLE AND PYRROLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-09 | — | — | WO | disclosed |