Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686299 | 0.85 | ABCG2 (0.67) | ABCG2LMNAMAPTATMSMN1; SMN2 | |
| SCHEMBL3687299 | 0.84 | ABCG2 (0.47) | ABCG2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL3684007 | 0.84 | ABCG2 (0.47) | ABCG2MAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL4854287 | 0.78 | PTPN1 (0.55) | PTPN1ABCG2IDH1ABCB1UGT1A1 | |
| SCHEMBL3684939 | 0.75 | TNFRSF1A (0.54) | ABCG2LMNAMAPTATMSMN1; SMN2 | |
| SCHEMBL3687801 | 0.74 | TNFRSF1A (0.67) | ABCG2LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL5915314 | 0.74 | PTPN1 (0.50) | PTPN1ABCG2IDH1ABCB1UGT1A1 | |
| SCHEMBL5915399 | 0.73 | ABCG2 (0.63) | PTPN1ABCG2LMNAMAPTATM | |
| SCHEMBL3687310 | 0.73 | ABCG2 (0.67) | ABCG2LMNAMAPTATMSMN1; SMN2 | |
| SCHEMBL3693509 | 0.73 | ABCG2 (0.67) | ABCG2LMNAMAPTATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |