Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686730 | 0.90 | KDM4E (0.47) | KDM4EGLAALDH1A1BRD4ATAD2 | |
| SCHEMBL10849986 | 0.84 | KMT2A (0.52) | KDM4EGLABRCA1SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL10847603 | 0.82 | KMT2A (0.51) | KDM4EGLABRCA1SMN1; SMN2HIF1A | |
| SCHEMBL6532561 | 0.81 | CNR2 (0.56) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| SCHEMBL12767048 | 0.80 | POLB (0.54) | SMN1; SMN2ALDH1A1HSD17B10NPC1POLB | |
| SCHEMBL14470975 | 0.78 | KDM4E (0.51) | KDM4EGLAALDH1A1HPGDHSD17B10 | |
| SCHEMBL1499558 | 0.78 | ALDH1A1 (0.56) | KDM4ESMN1; SMN2ALDH1A1HPGDNPC1 | |
| SCHEMBL1499550 | 0.77 | TSHR (0.58) | KDM4EALDH1A1PKMHPGDHSD17B10 | |
| SCHEMBL13033163 | 0.77 | KDM4E (0.51) | KDM4EGLASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL18474174 | 0.76 | SYK (0.53) | KDM4EGLAALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |