Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 14/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691669 | 1.00 | PTGS1 (0.52) | PTGS1PTGS2CXCL12MAOBMAOA | |
| SCHEMBL3690691 | 0.89 | CXCL12 (0.52) | CXCL12MAOBMAOAMEN1NPC1 | |
| SCHEMBL3686655 | 0.89 | CXCL12 (0.52) | CXCL12MAOBMAOAMEN1NPC1 | |
| SCHEMBL3697640 | 0.86 | MAOB (0.43) | MAOBMAOAHSP90AA1BCHEMEN1 | |
| SCHEMBL3694293 | 0.86 | MAOB (0.43) | MAOBMAOAHSP90AA1BCHEMEN1 | |
| SCHEMBL3685872 | 0.85 | MAOB (0.42) | MAOBMAOAHSP90AA1BCHEMEN1 | |
| SCHEMBL3690207 | 0.83 | BCHE (0.54) | MAOBBCHENPC1MAPTRAB9A | |
| SCHEMBL3687867 | 0.83 | BCHE (0.54) | MAOBBCHENPC1MAPTRAB9A | |
| SCHEMBL3688869 | 0.82 | MAOB (0.60) | CXCL12MAOBMAOABCHENPC1 | |
| SCHEMBL3689808 | 0.82 | MAOB (0.60) | CXCL12MAOBMAOABCHENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |