Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15475184 | 0.87 | ALDH1A1 (0.56) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL29126321 | 0.83 | GAA (0.52) | ALDH1A1GAAKMT2AMEN1KDM4E | |
| SCHEMBL15474866 | 0.82 | ALDH1A1 (0.50) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL3197069 | 0.81 | MAPT (0.61) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL15448633 | 0.77 | ALDH1A1 (0.56) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL11262976 | 0.77 | PIK3CD (0.68) | ALDH1A1GAAKMT2AMEN1GLA | |
| Hydrochloric Acid SCHEMBL25231967 | 0.76 | PIK3CD (0.66) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL3685781 | 0.76 | ADORA2A (0.51) | ALDH1A1GAAKMT2AMEN1GLA | |
| SCHEMBL3214435 | 0.76 | SIRT6 (0.66) | ALDH1A1MAPTMAPK1SIRT6 | |
| SCHEMBL15155902 | 0.75 | ALDH1A1 (0.78) | ALDH1A1GAAKMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |