Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | USP25 | Q9UHP3 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.32 |
| ▸ | USP2 | O75604 | 5/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.32 |
| ▸ | CASP1 | P29466 | 4/20 | 0.32 |
| ▸ | CASP7 | P55210 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368368 | 0.86 | ERCC1 (0.39) | HSD17B10LMNAUSP25CYP3A4CYP2C9 | |
| SCHEMBL368488 | 0.82 | CYP2C9 (0.41) | LMNACYP3A4CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL368920 | 0.81 | CYP2C9 (0.41) | ALDH1A1LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL368726 | 0.80 | PSMD14 (0.40) | ALDH1A1HSD17B10HPGDLMNAKDM4E | |
| SCHEMBL368702 | 0.80 | CYP2C9 (0.39) | HSD17B10HPGDLMNACYP3A4CYP2C9 | |
| SCHEMBL367823 | 0.74 | TTK (0.39) | ALDH1A1HSD17B10HPGDLMNAKDM4E | |
| SCHEMBL367927 | 0.74 | CYP2C9 (0.43) | HSD17B10LMNACYP3A4CYP2C9CYP2C19 | |
| SCHEMBL367904 | 0.72 | KCNH2 (0.37) | ALDH1A1HSD17B10HPGDLMNAKDM4E | |
| SCHEMBL10070421 | 0.71 | CALCA (0.49) | CYP3A4CYP2C9CYP2C19TP53SMN1; SMN2 | |
| SCHEMBL368029 | 0.70 | KCNH2 (0.43) | HSD17B10LMNACYP2C9MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593460-A1 | 7, 9-NITROGEN RADICAL-4-OXO-4H-PYRIDO[L,2-A]PYRIMIDINE-2-CARBOXYLIC ACID BENZYLAMIDE ANTI-VIRALS | Avexa Limited (AU) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012006680-A1 | 7, 9-NITROGEN RADICAL-4-OXO-4H-PYRIDO[L,2-A]PYRIMIDINE-2-CARBOXYLIC ACID BENZYLAMIDE ANTI-VIRALS | AVEXA LIMITED (AU) | 2012-01-19 | — | — | WO | disclosed |