Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078648 | 0.84 | TSHR (0.44) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL2404773 | 0.82 | RAF1 (0.51) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL3249150 | 0.82 | KDM4E (0.51) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL10265303 | 0.81 | RAF1 (0.50) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL31305747 | 0.79 | RAF1 (0.49) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL13315269 | 0.76 | RAF1 (0.46) | RAF1MAPTKMT2ALMNAGAA | |
| SCHEMBL577650 | 0.76 | MAPT (0.45) | RAF1MAPTTSHRKMT2AHSD17B10 | |
| SCHEMBL9529269 | 0.76 | TSHR (0.45) | MAPTTSHRKMT2AHSD17B10KDM4E | |
| SCHEMBL7670938 | 0.76 | TSHR (0.45) | MAPTTSHRKMT2AHSD17B10KDM4E | |
| SCHEMBL31305721 | 0.75 | RAF1 (0.45) | RAF1MAPTTSHRKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1964844-B1 | New thiophen glycoside derivatives, method for their manufacture, medicines containing these compounds and their application | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-09-01 | — | — | EP | disclosed |
| EP-1964845-B1 | New thiophen glycoside derivatives, method for their manufacture, medicines containing these compounds and their application | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-08-11 | — | — | EP | disclosed |
| EP-1967523-B1 | New thiophen glycoside derivatives, method for their manufacture, medicines containing these compounds and their application | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-08-11 | — | — | EP | disclosed |
| US-7666848-B2 | such as 3-(4-Methoxy-phenyl)-1-[3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-thiophen-2-yl]-propan-1-one; for use as antidiabetics | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-23 | — | — | US | disclosed |
| US-7666848-B2 | such as 3-(4-Methoxy-phenyl)-1-[3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-thiophen-2-yl]-propan-1-one; for use as antidiabetics | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-23 | — | — | US | disclosed |
| US-7666848-B2 | such as 3-(4-Methoxy-phenyl)-1-[3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-thiophen-2-yl]-propan-1-one; for use as antidiabetics | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-23 | — | — | US | disclosed |
| WO-2009138195-A2 | USE OF THIOPHENE GLYCOSIDE DERIVATIVES FOR PRODUCING MEDICAMENTS FOR TREATMENT OF HYPERTENSION | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-11-19 | — | — | WO | disclosed |
| EP-1523488-B1 | NOVEL THIOPHENYLGLYCOSIDE DERIVATIVES, METHODS FOR PRODUCTION THEREOF, MEDICAMENTS COMPRISING SAID COMPOUNDS AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-11-12 | — | — | EP | disclosed |
| EP-1967523-A1 | New thiophen glycoside derivatives, method for their manufacture, medicines containing these compounds and their application | Sanofi-Aventis Deutschland GmbH (DE) | 2008-09-10 | — | — | EP | disclosed |
| EP-1964845-A1 | New thiophen glycoside derivatives, method for their manufacture, medicines containing these compounds and their application | Sanofi-Aventis Deutschland GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| CN-101240000-A | Novel thiophenylglycoside derivatives, methods for production thereof, medicaments comprising said compounds and use thereof | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-08-13 | — | — | CN | disclosed |
| CN-100384863-C | Novel thienyl glycoside derivatives, method for the production thereof, medicaments containing said compounds and the use thereof | AVENTIS PHARMA GMBH (DE) | 2008-04-30 | — | — | CN | disclosed |
| US-20060293252-A1 | Novel Thiophene Glycoside Derivatives, Processes for The Preparation, Medicaments Comprising These Compounds, and The Use Thereof | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-12-28 | — | — | US | disclosed |
| US-7101856-B2 | Thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-09-05 | — | — | US | disclosed |
| CN-1668628-A | Novel thienyl glycoside derivatives, method for the production thereof, medicaments containing said compounds and the use thereof | AVENTIS PHARMA GMBH (DE) | 2005-09-14 | — | — | CN | disclosed |
| US-20040138143-A1 | Novel thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-07-15 | — | — | US | disclosed |
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138143-A1 | Novel thiophene glycoside derivatives, processes for the preparation, medicaments comprising these compounds, and the use thereof | SLC5A1, SLC5A2, UGGT1 | RAF1 2976/4885MAPT 4430/4885TSHR 1537/4885 |
| US-20060293252-A1 | Novel Thiophene Glycoside Derivatives, Processes for The Preparation, Medicaments Comprising These Compounds, and The Use Thereof | SLC5A2, SLC5A1, DPP4 | RAF1 3173/4885MAPT 4345/4885TSHR 1298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.