Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984909 | 0.90 | TSHR (0.38) | TSHRHSD17B10MGAMGAASI | |
| SCHEMBL31011228 | 0.87 | CA2 (0.47) | TSHRHSD17B10CA1CA2TDP1 | |
| SCHEMBL10682889 | 0.87 | CA2 (0.47) | TSHRHSD17B10CA1CA2TDP1 | |
| SCHEMBL14651155 | 0.87 | CA2 (0.47) | TSHRHSD17B10CA1CA2TDP1 | |
| SCHEMBL13610030 | 0.85 | ACE2 (0.48) | HSD17B10CA1CA2BIRC2ZDHHC7 | |
| SCHEMBL1739273 | 0.84 | TSHR (0.44) | TSHRHDAC7HDAC8HDAC6HDAC9 | |
| SCHEMBL16201901 | 0.84 | ACE2 (0.52) | HSD17B10BIRC2ZDHHC7MEN1HPGD | |
| SCHEMBL2254424 | 0.84 | ACE2 (0.52) | HSD17B10BIRC2ZDHHC7MEN1HPGD | |
| SCHEMBL28333296 | 0.84 | ACE2 (0.52) | HSD17B10BIRC2ZDHHC7MEN1HPGD | |
| SCHEMBL28851524 | 0.84 | ACE2 (0.52) | HSD17B10BIRC2ZDHHC7MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9108981-B2 | Cyclic P1 linkers as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-08-18 | — | — | US | disclosed |
| US-20150057262-A1 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS | NAVY, SECRETARY OF THE UNITED STATES OF AMERICA | 2015-02-26 | — | — | US | disclosed |
| US-8901115-B2 | Cyclic P1 linkers as factor XIa inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-12-02 | — | — | US | disclosed |
| US-20140163002-A1 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-06-12 | — | — | US | disclosed |
| CN-101880447-B | Polyester polyol used for high-weatherability coil coating and preparation method thereof | Zhangjiagang shunchang chemical co ltd | 2013-05-01 | — | — | CN | disclosed |
| EP-1527038-B1 | PROCESS FOR THE CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUDS | LUCITE INT UK LTD (GB) | 2010-03-17 | — | — | EP | disclosed |
| CN-1301955-C | Process for the carbonylation of ethylenically unsaturated compouds | LUCITE INT UK LTD (GB) | 2007-02-28 | — | — | CN | disclosed |
| CN-1675160-A | Process for the carbonylation of ethylenically unsaturated compouds | LUCITE INT UK LTD (GB) | 2005-09-28 | — | — | CN | disclosed |
| US-4775692-A | ANTILIPEMIC, ANTICOAGULANT, HYPOTENSIVE, ANTISECRETORY AND ANTIULCER AGENT | TORAY INDUSTRIES, INC. (JP) | 1988-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057262-A1 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS | F11, F12, F13A1 | TSHR 3059/4885HSD17B10 2893/4885MGAM 3588/4885 |
| US-20140163002-A1 | CYCLIC P1 LINKERS AS FACTOR XIA INHIBITORS | F11, F12, F13A1 | TSHR 3059/4885HSD17B10 2893/4885MGAM 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.