Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.41 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.41 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 7/20 | 0.41 |
| ▸ | HTR1B | P28222 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3686880 | 0.94 | KEAP1 (0.43) | HSP90AA1DNMT1MEN1KMT2AMAPT | |
| SCHEMBL3691047 | 0.91 | MEN1 (0.37) | MEN1KMT2AMAPTHTR1DKEAP1 | |
| SCHEMBL3687368 | 0.89 | KEAP1 (0.42) | MEN1KMT2AMAPTTNNI3TNNT2 | |
| SCHEMBL3687288 | 0.86 | BCHE (0.42) | MEN1KMT2AMAPTRELAALDH1A1 | |
| SCHEMBL3681669 | 0.85 | HDAC3 (0.41) | MEN1KMT2AALDH1A1DRD2 | |
| SCHEMBL3686500 | 0.85 | SMN1; SMN2 (0.44) | MEN1KMT2AMAPTHTR1DHTR1B | |
| SCHEMBL3690742 | 0.85 | SMN1; SMN2 (0.44) | MEN1KMT2AMAPTHTR1DHTR1B | |
| SCHEMBL3685026 | 0.84 | KEAP1 (0.42) | MEN1KMT2AMAPTTNNI3TNNT2 | |
| SCHEMBL4852794 | 0.81 | MCHR1 (0.45) | HSP90AA1DNMT1MEN1KMT2ATNFRSF1A | |
| SCHEMBL3688376 | 0.81 | LMNA (0.42) | HSP90AA1MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | claimed |
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |
| EP-1506158-A2 | DIAMINO-FUNCTIONAL CHALCONES | Lica Pharmaceuticals A/S (DK) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097576-A2 | DIAMINO-FUNCTIONAL CHALCONES | LICA PHARMACEUTICALS A/S (DK) | 2003-11-27 | — | — | WO | disclosed |