Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691571 | 1.00 | HDAC1 (0.47) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3691487 | 0.92 | HDAC4 (0.40) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3693761 | 0.92 | HDAC4 (0.40) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3686567 | 0.84 | PRKD1 (0.39) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3689620 | 0.82 | SYK (0.39) | HDAC4SYKALDH1A1PIM2MEN1 | |
| SCHEMBL3697631 | 0.82 | SYK (0.39) | HDAC4SYKALDH1A1PIM2MEN1 | |
| SCHEMBL4854769 | 0.80 | SYK (0.45) | SYK | |
| SCHEMBL4852884 | 0.80 | SYK (0.45) | SYK | |
| SCHEMBL3687249 | 0.79 | HDAC1 (0.54) | HDAC1HDAC8HDAC6HDAC3HDAC4 | |
| SCHEMBL3693788 | 0.79 | HDAC1 (0.54) | HDAC1HDAC8HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |