Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | MEF2D | Q14814 | 3/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3697631 | 1.00 | SYK (0.39) | SYKHDAC4MEF2DPIM2HCRTR2 | |
| SCHEMBL4852884 | 0.84 | SYK (0.45) | SYKHCRTR2MAOB | |
| SCHEMBL4854769 | 0.84 | SYK (0.45) | SYKHCRTR2MAOB | |
| SCHEMBL3689622 | 0.82 | HCRTR2 (0.38) | SYKHCRTR2NOS1NOS2MEN1 | |
| SCHEMBL3691571 | 0.82 | HDAC1 (0.47) | SYKHDAC4PIM2MEN1KMT2A | |
| SCHEMBL3686566 | 0.82 | HDAC1 (0.47) | SYKHDAC4PIM2MEN1KMT2A | |
| SCHEMBL3693761 | 0.82 | HDAC4 (0.40) | SYKHDAC4MEF2DPIM2HCRTR2 | |
| SCHEMBL3691487 | 0.82 | HDAC4 (0.40) | SYKHDAC4MEF2DPIM2HCRTR2 | |
| SCHEMBL4847745 | 0.73 | SYK (0.47) | SYKMCHR1MAOB | |
| SCHEMBL4853606 | 0.73 | SYK (0.47) | SYKMCHR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |