Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.45 |
| ▸ | PPARG | P37231 | 7/20 | 0.45 |
| ▸ | PPARD | Q03181 | 7/20 | 0.45 |
| ▸ | PPARA | Q07869 | 7/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | TLR2 | O60603 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | FABP4 | P15090 | 2/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL3691967 | 0.94 | ALDH1A1 (0.59) | ALDH1A1TSHRCYP3A4AKR1B1GPR84 | |
| Succinic Acid SCHEMBL2690032 | 0.92 | AKR1B1 (0.54) | ALDH1A1TSHRCYP3A4AKR1B1GPR84 | |
| Succinic Acid SCHEMBL12980700 | 0.89 | AKR1B1 (0.56) | ALDH1A1TSHRCYP3A4AKR1B1GPR84 | |
| Acetic Acid SCHEMBL6031990 | 0.88 | CYP3A4 (0.52) | ALDH1A1TSHRCYP3A4MEN1KMT2A | |
| Succinic Acid SCHEMBL4803416 | 0.87 | ALDH1A1 (0.56) | ALDH1A1TSHRSLC22A6HSD17B10OR51E2 | |
| Valeric Acid SCHEMBL2247331 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TSHRAKR1B1GPR84PPARG | |
| SCHEMBL31424150 | 0.86 | TSHR (0.47) | ALDH1A1TSHRCYP3A4MEN1KMT2A | |
| Dodecanoate SCHEMBL30912229 | 0.86 | GPR84 (0.65) | ALDH1A1TSHRAKR1B1GPR84PPARG | |
| Dodecanoate SCHEMBL29267330 | 0.86 | GPR84 (0.65) | ALDH1A1TSHRAKR1B1GPR84PPARG | |
| Succinic Acid SCHEMBL3687282 | 0.86 | AKR1B1 (0.48) | ALDH1A1TSHRCYP3A4AKR1B1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7803298-B2 | Molding material, molded part, and method for manufacturing them | SUMITOMO ELECTRIC FINE POLYMER, INC. (JP) | 2010-09-28 | — | — | US | disclosed |
| US-20090030160-A1 | Polylactic Acid Complex and Production Method Thereof | SUMITOMO ELECTRIC FINE POLYMER INC. (JP) | 2009-01-29 | — | — | US | disclosed |
| US-20080036119-A1 | Molding material, molded part, and method for manufacturing them | SUMITOMO ELECTRIC FINE POLYMER, INC. | 2008-02-14 | — | — | US | disclosed |