Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 10/20 | 0.41 |
| ▸ | PPARA | Q07869 | 9/20 | 0.41 |
| ▸ | PPARG | P37231 | 8/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.37 |
| ▸ | PFKFB4 | Q16877 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3682620 | 0.93 | PFKFB4 (0.37) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL3688599 | 0.89 | PPARD (0.48) | PPARDPPARAPPARGALDH1A1GAA | |
| SCHEMBL3681617 | 0.87 | PPARD (0.40) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL3683718 | 0.83 | PPARD (0.51) | PPARDPPARGPFKFB3PFKFB4 | |
| SCHEMBL13508489 | 0.82 | CMA1 (0.41) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL3756003 | 0.82 | PPARA (0.41) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL3695390 | 0.81 | PPARD (0.43) | PPARDPPARGPFKFB3PFKFB4 | |
| SCHEMBL3688961 | 0.81 | PPARD (0.48) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL13508526 | 0.80 | PPARA (0.40) | PPARDPPARAPPARGPFKFB3PFKFB4 | |
| SCHEMBL3689893 | 0.79 | PPARD (0.48) | PPARDPPARAPPARGPFKFB3PFKFB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-7655641-B2 | Sulfonamide derivatives as PPAR modulators | ELI LILLY AND COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| EP-1597248-B1 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | LILLY CO ELI (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1597248-B1 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | LILLY CO ELI (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1597248-A2 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004073606-A2 | SULFONAMIDE DERIVATIVES AS PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-09-02 | — | — | WO | disclosed |