Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 5/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091350 | 0.77 | BRD3 (0.57) | SIRT1SIRT2 | |
| SCHEMBL4159842 | 0.74 | DHODH (0.66) | MAPKAPK2SIRT1HTR1BSIRT2SIRT3 | |
| SCHEMBL5467992 | 0.73 | RB1 (0.62) | MAPKAPK2SIRT1HTR1BSIRT2SIRT3 | |
| SCHEMBL6447738 | 0.70 | F2 (0.74) | MAPKAPK2HTR1BMAPTHTR1AHTR1D | |
| SCHEMBL29643283 | 0.70 | F2 (0.74) | MAPKAPK2HTR1BMAPTHTR1AHTR1D | |
| Oxalic Acid SCHEMBL9336199 | 0.69 | BRD3 (0.46) | MAPKAPK2SIRT1SIRT2SIRT3RECQL | |
| SCHEMBL5454077 | 0.69 | CDC42 (0.58) | MAPKAPK2SIRT1HTR1BSIRT2SIRT3 | |
| SCHEMBL5458948 | 0.69 | BRD3 (0.55) | MAPKAPK2MAPTALOX15MAPK1SMN1; SMN2 | |
| SCHEMBL6238342 | 0.68 | MAPKAPK2 (1.00) | MAPKAPK2SIRT1HTR1BHTR1AHTR1D | |
| SCHEMBL30833215 | 0.68 | KCNH2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190838-A1 | CANNABINOID RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2010-06-02 | — | — | EP | claimed |
| WO-2009024819-A1 | CANNABINOID RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | claimed |
| EP-2190838-A1 | CANNABINOID RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024819-A1 | CANNABINOID RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |