Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 1/20 | 0.57 |
| ▸ | RB1 | P06400 | 7/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SSTR3 | P32745 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687747 | 0.77 | MAPKAPK2 (0.52) | SIRT1SIRT2 | |
| SCHEMBL3805259 | 0.77 | HTR2A (0.68) | SSTR3KCNH2CACNA1FCACNA1DCACNA1S | |
| SCHEMBL1871473 | 0.73 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL7088610 | 0.73 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL20960591 | 0.73 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL1877922 | 0.73 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL29625801 | 0.73 | BRD3 (0.67) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL10924730 | 0.73 | BRD3 (1.00) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL9665012 | 0.72 | BRD3 (0.65) | BRD3RB1SIRT1SIRT2ADRA1D | |
| SCHEMBL9610870 | 0.72 | BRD3 (0.65) | BRD3RB1SIRT1SIRT2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062251-A1 | Novel Compounds 002 | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062251-A1 | Novel Compounds 002 | OPRL1, OPRK1, OPRM1 | BRD3 4357/4885RB1 914/4885SIRT1 4021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.