Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 1.00 |
| ▸ | RXRB | P28702 | 14/20 | 1.00 |
| ▸ | RXRG | P48443 | 14/20 | 1.00 |
| ▸ | RARB | P10826 | 13/20 | 1.00 |
| ▸ | RARG | P13631 | 12/20 | 1.00 |
| ▸ | RARA | P10276 | 8/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688713 | 1.00 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL3688709 | 1.00 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL10937274 | 0.87 | RXRA (0.77) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL10937270 | 0.87 | RXRA (0.77) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7219495 | 0.85 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7219497 | 0.85 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6263315 | 0.85 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6263321 | 0.85 | RXRA (0.74) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5929415 | 0.80 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9128385 | 0.79 | RXRA (1.00) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461028-A4 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | UNIV CALIFORNIA (US) | 2007-07-25 | — | — | EP | claimed |
| WO-2004098506-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-11-18 | — | — | WO | claimed |
| EP-1461028-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | The Regent of the University of California (US) | 2004-09-29 | — | — | EP | claimed |
| US-20030229062-A1 | Treatments for age-related macular degeneration (AMD) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-12-11 | — | — | US | claimed |
| US-20030162758-A1 | Treatment for age-related macular degeneration (AMD) | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2003-08-28 | — | — | US | claimed |
| WO-2003049685-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-06-19 | — | — | WO | claimed |
| US-20100047330-A1 | TREATMENT FOR DARK ADAPTATION | THE REGENTS OF THE UNIVERSTIY OF CALIFORNIA | 2010-02-25 | — | — | US | disclosed |
| US-7470660-B2 | Treatment for dark adaptation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470659-B2 | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1461028-A4 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | UNIV CALIFORNIA (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20050282750-A1 | Treatment for dark adaptation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-12-22 | — | — | US | disclosed |
| WO-2005091909-A2 | METHODS TO INCREASE REVERSE CHOLESTEROL TRANSPORT IN THE RETINAL PIGMENT EPITHELIUM (RPE) AND BRUCH’S MEMBRANE (BM) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-10-06 | — | — | WO | disclosed |
| US-20040266663-A1 | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and bruch's membrane (BM) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-12-30 | — | — | US | disclosed |
| WO-2004098506-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-11-18 | — | — | WO | disclosed |
| EP-1461028-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | The Regent of the University of California (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20030229062-A1 | Treatments for age-related macular degeneration (AMD) | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-12-11 | — | — | US | disclosed |
| US-20030162758-A1 | Treatment for age-related macular degeneration (AMD) | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2003-08-28 | — | — | US | disclosed |
| WO-2003049685-A2 | TREATMENT FOR AGE-RELATED MACULAR DEGENERATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-06-19 | — | — | WO | disclosed |