Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781 | 0.88 | — | — | |
| SCHEMBL56331 | 0.88 | CA2 (0.54) | CA2TSHRTDP1CA1CA9 | |
| Benzene SCHEMBL9320024 | 0.85 | CA2 (0.44) | CA2TSHRTDP1CA1CA9 | |
| Sulfuric Acid SCHEMBL560688 | 0.84 | CA5A (0.55) | CA2TSHRTDP1CA1CA9 | |
| Water SCHEMBL2456364 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 | |
| Water SCHEMBL10934974 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 | |
| Phosphine SCHEMBL10457030 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 | |
| Methane SCHEMBL7363776 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 | |
| SCHEMBL10495537 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 | |
| SCHEMBL337658 | 0.84 | CA2 (0.50) | CA2TSHRTDP1CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100143473-A1 | COMBINATION TREATMENT WITH STRONTIUM FOR THE PROPHYLAXIS AND/OR TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | OSTEOLOGIX A/S | 2010-06-10 | — | — | US | claimed |
| US-20060275503-A1 | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions | NORDIC BONE A/S (DK) | 2006-12-07 | — | — | US | claimed |
| EP-1622630-A2 | STRONTIUM COMBINATIONS FOR THE PROPHYLAXIS/TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | Osteologix A/S (DK) | 2006-02-08 | — | — | EP | claimed |
| WO-2004098618-A2 | STRONTIUM COMBINATIONS FOR PROPHYLAXIS/TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | OSTEOLOGIX A/S (DK) | 2004-11-18 | — | — | WO | claimed |
| CN-103534250-B | Be used for the treatment of the substituted indole derivatives of dysimmunity | Switzerland Novartis Animal Health Co.,Ltd. (CH) | 2016-05-11 | — | — | CN | disclosed |
| US-8623422-B2 | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions | OSTEOLOGIX A/S (DK) | 2014-01-07 | — | — | US | disclosed |
| EP-2266584-A2 | Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions | Osteologix A/S (DK) | 2010-12-29 | — | — | EP | disclosed |
| US-20100143473-A1 | COMBINATION TREATMENT WITH STRONTIUM FOR THE PROPHYLAXIS AND/OR TREATMENT OF CARTILAGE AND/OR BONE CONDITIONS | OSTEOLOGIX A/S | 2010-06-10 | — | — | US | disclosed |
| US-20060275503-A1 | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions | NORDIC BONE A/S (DK) | 2006-12-07 | — | — | US | disclosed |