Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | HNF4A | P41235 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA4 | P22748 | 2/20 | 0.45 |
| ▸ | CA7 | P43166 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098212 | 0.98 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL29633266 | 0.96 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL9109 | 0.96 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Ammonia Solution, Strong SCHEMBL7767435 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Water SCHEMBL10709467 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL17200169 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Water SCHEMBL7762373 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL3332893 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Hydrochloric Acid SCHEMBL2584553 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL17076506 | 0.94 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005683-A1 | GLYCINE BETAINE AND ITS USE | MESSADEK JALLAL (BE) | 2013-01-03 | — | — | US | claimed |
| US-20100004199-A1 | GLYCINE BETAINE AND ITS USE | MESSADEK JALLAL | 2010-01-07 | — | — | US | claimed |
| EP-1408949-B1 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | MESSADEK JALLAL (BE) | 2007-12-19 | — | — | EP | claimed |
| EP-1408949-A2 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | Messadek, Jallal (BE) | 2004-04-21 | — | — | EP | claimed |
| US-20040033223-A1 | Glycine betaine and its use | MESSADEK JALLAL (BE) | 2004-02-19 | — | — | US | claimed |
| WO-2002062322-A2 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | MESSADEK JALLAL (BE) | 2002-08-15 | — | — | WO | claimed |
| US-20130005683-A1 | GLYCINE BETAINE AND ITS USE | MESSADEK JALLAL (BE) | 2013-01-03 | — | — | US | disclosed |
| US-20100004199-A1 | GLYCINE BETAINE AND ITS USE | MESSADEK JALLAL | 2010-01-07 | — | — | US | disclosed |
| US-7608640-B2 | Curative and preventive activity in the pathogenesis of thrombo-embolic and haemostatic diseases of arterial or venous origin | MESSADEK JALLAL | 2009-10-27 | — | — | US | disclosed |
| EP-1408949-B1 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | MESSADEK JALLAL (BE) | 2007-12-19 | — | — | EP | disclosed |
| EP-1408949-A2 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | Messadek, Jallal (BE) | 2004-04-21 | — | — | EP | disclosed |
| US-20040033223-A1 | Glycine betaine and its use | MESSADEK JALLAL (BE) | 2004-02-19 | — | — | US | disclosed |
| WO-2002062322-A2 | GLYCINE BETAINE AND ITS USE AS ANTI-HEMORRHAGIC AGENT | MESSADEK JALLAL (BE) | 2002-08-15 | — | — | WO | disclosed |