Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | ALB | P02768 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | HNF4A | P41235 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9109 | 0.98 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL29633266 | 0.98 | ALDH1A1 (0.63) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL17200169 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Water SCHEMBL7762373 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL17076506 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Water SCHEMBL10709467 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| SCHEMBL4098212 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Ammonia Solution, Strong SCHEMBL7767435 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Hydrochloric Acid SCHEMBL2584553 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDHSD17B10ALB | |
| Bicarbonate SCHEMBL3689372 | 0.94 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDHSD17B10ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618120-B2 | Synergistic combinations of VR-1 antagonists and COX-2 inhibitors | NOVARTIS AG (CH) | 2013-12-31 | — | — | US | disclosed |
| US-20100144740-A1 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS | NOVARTIS AG (CH) | 2010-06-10 | — | — | US | disclosed |
| EP-2178562-A1 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS | Novartis Ag (CH) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009010529-A1 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS | NOVARTIS AG (CH) | 2009-01-22 | — | — | WO | disclosed |
| US-3988333-A | Tri-substituted aluminum salts or di-substituted aluminum salts of carboxyl group-containing, pharmaceutically effective compounds | TEIKOKU HORMONE MFG. CO., LTD. (JA) | 1976-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144740-A1 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS | TRPV2, TRPV1, TRPV3 | ALDH1A1 1168/4885KDM4E 4559/4885HPGD 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.