SCHEMBL3690740

SCHEMBL3690740

C1=NC2=C(CC1)NCCC2

nearest known ligand 0.30

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2505713 0.65 LMNA (0.32) OR51E2
SCHEMBL765239 0.64
SCHEMBL12179455 0.64
SCHEMBL8866832 0.62 OR51E2 (0.47) OR51E2
SCHEMBL2497721 0.61 UHRF1 (0.34)
SCHEMBL12498079 0.60 OR51E2 (0.31) OR51E2
SCHEMBL2497719 0.58 OR51E2 (0.30) OR51E2
SCHEMBL3694424 0.58 PNMT (0.30)
SCHEMBL3694516 0.58 PNMT (0.30)
SCHEMBL11983397 0.57

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010077740-A2 NOVEL ANTIVIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE CYTOKINE PHARMASCIENCES, INC. (US) 2010-07-08 WO claimed
US-10479794-B2 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2019-11-19 US disclosed
US-20180134720-A1 CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE BOEHRINGER INGELHEIM INT (DE) 2018-05-17 US disclosed
WO-2010077740-A2 NOVEL ANTIVIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE CYTOKINE PHARMASCIENCES, INC. (US) 2010-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10479794-B2 Cyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxyamide CNP, PDE5A, PDE3A OR51E2 3367/4885
US-20180134720-A1 CYCLIC ETHER DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYAMIDE CNP, PDE5A, PDE3A OR51E2 3367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.