Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699158 | 0.85 | OPRM1 (0.52) | P2RY1OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3697396 | 0.84 | OPRM1 (0.63) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL27549454 | 0.83 | OPRM1 (0.46) | HRH3OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3698501 | 0.82 | OPRM1 (0.57) | P2RY1OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3692009 | 0.81 | ACACB (0.46) | OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3694536 | 0.81 | OPRM1 (0.62) | HRH3OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3694396 | 0.80 | OPRM1 (0.63) | HRH3OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3692086 | 0.79 | OPRM1 (0.68) | P2RY1OPRM1OPRD1OPRK1ABCB1 | |
| SCHEMBL3696693 | 0.79 | HRH3 (0.56) | HRH3OPRM1OPRD1OPRK1 | |
| SCHEMBL3698655 | 0.79 | OPRM1 (0.63) | HRH3OPRM1OPRD1OPRK1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |