Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11332440 | 0.98 | MCL1 (0.53) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL31266402 | 0.98 | MCL1 (0.53) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| Potassium Ion SCHEMBL29653831 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL29653826 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL78761 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL5078513 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL31134735 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| Potassium Ion SCHEMBL3009008 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| SCHEMBL31134782 | 0.96 | MCL1 (0.52) | MCL1ALDH1A1TSHRL3MBTL1HPGD | |
| Lithium Ion SCHEMBL3699048 | 0.83 | S100A4 (0.46) | MCL1ALDH1A1TSHRL3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079830-B2 | Method for producing biaryl compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-07-14 | — | — | US | disclosed |
| US-20120123154-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-05-17 | — | — | US | disclosed |
| US-4147545-A | FOR DIAZO-SENSITIZED PHOTOSENSITIVE COATINGS | POLYCHROME CORPORATION (US) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123154-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | AKR7A2, AOC2, CBR1 | MCL1 393/4885ALDH1A1 35/4885TSHR 1160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.