Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.55 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6050485 | 1.00 | MAPT (0.59) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3694613 | 0.92 | ABCG2 (0.62) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3690293 | 0.92 | ABCG2 (0.62) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3685701 | 0.88 | MAOB (0.55) | MAPTLMNAABCG2NPC1ALDH1A1 | |
| SCHEMBL3695219 | 0.87 | PDE4A (0.59) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3682208 | 0.86 | LMNA (0.50) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3690295 | 0.85 | MAPT (0.60) | MAPTSMN1; SMN2LMNAABCG2PDE4A | |
| SCHEMBL4856281 | 0.84 | MAPT (0.60) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL4856367 | 0.84 | MAPT (0.60) | MAPTSMN1; SMN2LMNAGAAATM | |
| SCHEMBL3691415 | 0.84 | TNFRSF1A (0.50) | ABCG2TNFRSF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |