Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088340 | 0.88 | ALOX5 (0.54) | NPC1ALOX5CASP3SENP7SENP6 | |
| SCHEMBL22222028 | 0.86 | HDAC6 (0.52) | NPC1ALOX5CASP3SENP7SENP6 | |
| SCHEMBL20466823 | 0.85 | HDAC6 (0.43) | NPC1ALOX5CASP3SENP7SENP6 | |
| SCHEMBL6583412 | 0.78 | ALOX5 (0.66) | NPC1ALOX5IKBKBCHUKMAOB | |
| SCHEMBL19346119 | 0.77 | HDAC6 (0.43) | NPC1ALOX5CASP3SENP7SENP6 | |
| SCHEMBL13201323 | 0.76 | GSK3B (0.58) | NPC1ALOX5MAOBMAOATRPA1 | |
| SCHEMBL19217080 | 0.76 | ALOX5 (0.42) | NPC1ALOX5CASP3SENP7SENP6 | |
| SCHEMBL4659168 | 0.75 | MAOB (0.78) | NPC1ALOX5MAOBADRA2AMAOA | |
| SCHEMBL223274 | 0.75 | PTPRC (0.59) | NPC1ALOX5IKBKBCHUKMAOB | |
| SCHEMBL29791652 | 0.75 | PTPRC (0.59) | NPC1ALOX5IKBKBCHUKMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | UNIV YALE (US) | 2025-01-02 | — | — | US | disclosed |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2024-08-27 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2023-06-29 | — | — | US | disclosed |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2023-03-14 | — | — | US | disclosed |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2021-03-04 | — | — | US | disclosed |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | NATIONAL SCIENCE FOUNDATION | 2021-03-04 | — | — | US | disclosed |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-19 | — | — | US | disclosed |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | YALE UNIVERSITY (US) | 2021-01-19 | — | — | US | disclosed |
| US-9006463-B2 | Slow release of organoboronic acids in cross-coupling reactions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-14 | — | — | US | disclosed |
| US-9006463-B2 | Slow release of organoboronic acids in cross-coupling reactions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-14 | — | — | US | disclosed |
| US-20130317223-A1 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-11-28 | — | — | US | disclosed |
| US-8338601-B2 | Slow release of organoboronic acids in cross-coupling reactions | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338601-B2 | Slow release of organoboronic acids in cross-coupling reactions | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-12-25 | — | — | US | disclosed |
| US-7772256-B2 | 2-heteroaryl substituted benzothiophenes and benzofuranes 709 | ASTRAZENECA AB (SE) | 2010-08-10 | — | — | US | disclosed |
| US-20100121062-A1 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100121062-A1 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-05-13 | — | — | US | disclosed |
| WO-2010036921-A2 | SLOW RELEASE OF ORGANOBORONIC ACIDS IN CROSS-COUPLING REACTIONS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-04-01 | — | — | WO | disclosed |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | ASTRAZENECA AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250002519-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | NPC1 4247/4885ALOX5 2144/4885CASP3 3914/4885 |
| US-20100121062-A1 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions | BRS3, CD79B, GRB2 | NPC1 1531/4885ALOX5 3480/4885CASP3 293/4885 |
| US-11603381-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | NPC1 3836/4885ALOX5 2404/4885CASP3 3547/4885 |
| US-20210061834-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | NPC1 4247/4885ALOX5 2144/4885CASP3 3914/4885 |
| US-20230203077-A1 | NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME | TIMCC, YAP1, TET2 | NPC1 4247/4885ALOX5 2144/4885CASP3 3914/4885 |
| US-20130317223-A1 | Slow Release of Organoboronic Acids in Cross-Coupling Reactions | BRS3, CD79B, GRB2 | NPC1 1531/4885ALOX5 3480/4885CASP3 293/4885 |
| US-20080221149-A1 | 2-[6-(methylamino)pyridin-3-yl]-1-benzofuran-5-ol; for imaging amyloid deposits in living patients | PSEN1, APP, PSEN2 | NPC1 462/4885ALOX5 695/4885CASP3 2587/4885 |
| US-10894802-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | NPC1 3836/4885ALOX5 2404/4885CASP3 3547/4885 |
| US-12071445-B2 | Precatalyst scaffolds for cross-coupling reactions, and methods of making and using same | TIMCC, YAP1, TET2 | NPC1 3836/4885ALOX5 2404/4885CASP3 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.