Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700225 | 0.94 | HTR2C (0.39) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3700978 | 0.93 | HTR2C (0.45) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3698587 | 0.90 | HTR2C (0.42) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3697673 | 0.89 | HTR2C (0.39) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL4131270 | 0.88 | ALDH1A1 (0.37) | KDM4EALDH1A1CYP2D6MEN1KMT2A | |
| SCHEMBL3705902 | 0.87 | HTR2C (0.39) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3703585 | 0.87 | HTR2C (0.41) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3700004 | 0.87 | HTR2C (0.39) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3814403 | 0.87 | HTR2C (0.38) | HTR2CSLC6A4HTR2AKAT6AKAT5 | |
| SCHEMBL3698341 | 0.85 | HTR2C (0.38) | HTR2CSLC6A4HTR2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |