Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3700225 | 0.92 | HTR2C (0.39) | HTR2CSLC6A4HTR2AGPR119F2 | |
| SCHEMBL3700608 | 0.91 | HTR2C (0.40) | HTR2CSLC6A4HTR2ANAMPTTSHR | |
| SCHEMBL3701316 | 0.89 | HTR2C (0.38) | HTR2CSLC6A4HTR2ANAMPTF2 | |
| SCHEMBL3700700 | 0.89 | HTR2C (0.38) | HTR2CSLC6A4HTR2ANAMPTF2 | |
| SCHEMBL3709941 | 0.88 | PTGS2 (0.33) | NAMPTMAPTPTGS2TSHR | |
| SCHEMBL3706785 | 0.87 | HTR2C (0.40) | HTR2CSLC6A4HTR2ALMNATP53 | |
| SCHEMBL3697102 | 0.85 | HTR2C (0.41) | HTR2CSLC6A4HTR2ANAMPT | |
| SCHEMBL3696324 | 0.85 | HTR2C (0.40) | HTR2CSLC6A4HTR2AF2 | |
| SCHEMBL3688570 | 0.85 | HTR2C (0.38) | HTR2CSLC6A4HTR2ALMNATSHR | |
| SCHEMBL3703100 | 0.84 | HTR2C (0.36) | HTR2CSLC6A4HTR2ANAMPTF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |