Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 10/20 | 0.50 |
| ▸ | GAA | P10253 | 10/20 | 0.50 |
| ▸ | SI | P14410 | 10/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 10/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.46 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369738 | 1.00 | MGAM (0.50) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL1390916 | 0.84 | MGAM (0.53) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL1390521 | 0.84 | MGAM (0.53) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL370252 | 0.84 | MGAM (0.53) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL1390493 | 0.81 | GPBAR1 (0.45) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL1390495 | 0.81 | GPBAR1 (0.45) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL368669 | 0.80 | GPBAR1 (0.49) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL368670 | 0.80 | GPBAR1 (0.49) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL14936474 | 0.79 | GPBAR1 (0.47) | MGAMGAASIMGAM2GPBAR1 | |
| SCHEMBL14936693 | 0.79 | GPBAR1 (0.47) | MGAMGAASIMGAM2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8765730-B2 | 1-hydroxyimino-3-phenyl-propanes | Hoffmann-La Roche Inc (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010190-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | GPBAR1, GPR119, ADRB1 | MGAM 2443/4885GAA 2696/4885SI 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.