Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL163545 | 0.79 | CYP2C9 (0.63) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL370989 | 0.75 | KMT2A (0.40) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL2220291 | 0.73 | ENPP2 (0.36) | KMT2AMEN1ENPP2 | |
| SCHEMBL255707 | 0.72 | GAA (0.48) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL13275030 | 0.72 | KMT2A (0.38) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL16330890 | 0.72 | KDM5A (0.47) | CYP2C9KMT2AMEN1KDM5ACHEK1 | |
| SCHEMBL13449431 | 0.71 | CYP2C9 (0.58) | CYP2C9KMT2AMEN1GAAALDH1A1 | |
| SCHEMBL13275029 | 0.71 | CYP2C9 (0.36) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL368618 | 0.71 | CYP2C9 (0.36) | CYP2C9KMT2AMEN1GAAKDM5A | |
| SCHEMBL367892 | 0.71 | CYP2C9 (0.36) | CYP2C9KMT2AMEN1GAAKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2515657-A1 | TYROSINE KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |