Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 7/20 | 0.33 |
| ▸ | CTSV | O60911 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269058 | 0.88 | ENPP2 (0.41) | ENPP2METHSD17B13MEN1KMT2A | |
| SCHEMBL2273583 | 0.88 | ENPP2 (0.33) | ENPP2METHSD17B13MEN1KMT2A | |
| SCHEMBL13275650 | 0.86 | ENPP2 (0.35) | ENPP2METHSD17B13MEN1KMT2A | |
| SCHEMBL2220270 | 0.86 | ENPP2 (0.39) | ENPP2METHSD17B13MEN1KMT2A | |
| SCHEMBL2271291 | 0.85 | HSD17B13 (0.38) | ENPP2METHSD17B13IRAK4IRAK1 | |
| SCHEMBL2273580 | 0.85 | ENPP2 (0.34) | ENPP2METHSD17B13IRAK4IRAK1 | |
| SCHEMBL2261414 | 0.85 | HSD17B13 (0.42) | ENPP2METHSD17B13IRAK4IRAK1 | |
| SCHEMBL2266288 | 0.85 | ENPP2 (0.35) | ENPP2METHSD17B13MEN1KMT2A | |
| SCHEMBL13275123 | 0.84 | HSD17B13 (0.37) | ENPP2METHSD17B13IRAK4IRAK1 | |
| SCHEMBL2268897 | 0.84 | HSD17B13 (0.39) | ENPP2METHSD17B13IRAK4IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | claimed |
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-10-18 | — | — | US | disclosed |
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | ABL1, MET, ERBB2 | ENPP2 1293/4885MET 2/4885HSD17B13 3914/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.