Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | TEK | Q02763 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59458 | 0.86 | KMT2A (0.66) | RAB9ANPC1L3MBTL1LMNAPDGFRB | |
| SCHEMBL424231 | 0.86 | RAB9A (0.55) | RAB9ANPC1L3MBTL1LMNACYP1A2 | |
| SCHEMBL3665719 | 0.86 | PDGFRB (0.62) | RAB9ANPC1L3MBTL1SMN1; SMN2TP53 | |
| SCHEMBL59554 | 0.83 | KDR (0.49) | RAB9ANPC1L3MBTL1SMN1; SMN2PDGFRB | |
| SCHEMBL57876 | 0.81 | KDR (0.52) | PDGFRBKDRKMT2AMEN1 | |
| SCHEMBL3666256 | 0.80 | SMN1; SMN2 (0.59) | RAB9ANPC1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL14872842 | 0.78 | DGAT1 (0.48) | L3MBTL1PDGFRBKDR | |
| SCHEMBL64906 | 0.78 | KDR (0.64) | RAB9ANPC1PDGFRBKDRTEK | |
| SCHEMBL59353 | 0.78 | EPHX2 (0.44) | L3MBTL1SMN1; SMN2PDGFRBKDRKMT2A | |
| SCHEMBL29216909 | 0.77 | MEN1 (0.49) | RAB9ANPC1L3MBTL1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2452937-A1 | Inhibitors of diacylglycerol o-acyltransferase type 1 enzyme | Abbott Laboratories (US) | 2012-05-16 | — | — | EP | disclosed |