Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 8/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3696583 | 0.89 | HTR2C (0.51) | HTR2CSLC6A4SLC16A3SLC16A1HTR2A | |
| SCHEMBL4125824 | 0.88 | SLC16A3 (0.38) | HTR2CSLC6A4SLC16A3SLC16A1MAPT | |
| SCHEMBL3706235 | 0.85 | HTR2C (0.49) | HTR2CSLC6A4SLC16A3SLC16A1 | |
| SCHEMBL3029602 | 0.84 | HTR2C (0.49) | HTR2CSLC6A4SLC16A3SLC16A1HTR2A | |
| SCHEMBL3702179 | 0.83 | HTR2C (0.43) | HTR2CSLC6A4SLC16A3SLC16A1LMNA | |
| SCHEMBL3694434 | 0.82 | HTR2C (0.48) | HTR2CSLC6A4SLC16A3SLC16A1 | |
| SCHEMBL3698141 | 0.82 | SLC16A3 (0.37) | SLC16A3SLC16A1MEN1KMT2A | |
| SCHEMBL3701898 | 0.82 | HTR2C (0.49) | HTR2CSLC6A4SLC16A3SLC16A1MAPT | |
| SCHEMBL3700571 | 0.82 | HTR2C (0.47) | HTR2CSLC6A4SLC16A3SLC16A1HTR2A | |
| SCHEMBL3692821 | 0.80 | HTR2C (0.49) | HTR2CSLC6A4SLC16A3SLC16A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009041705-A9 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009041705-A2 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-04-02 | — | — | WO | disclosed |