Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 9/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | NAMPT | P43490 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.58 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.58 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701861 | 0.85 | NPC1 (0.64) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3701749 | 0.85 | NAMPT (0.85) | RAB9ANPC1NAMPTSMN1; SMN2KMT2A | |
| SCHEMBL3698631 | 0.84 | NAMPT (0.64) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3698236 | 0.83 | NAMPT (0.84) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3707242 | 0.81 | RAB9A (0.73) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3700315 | 0.81 | NAMPT (0.65) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3705329 | 0.80 | RAB9A (0.75) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3696624 | 0.79 | NAMPT (0.87) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3701456 | 0.79 | RAB9A (0.67) | RAB9ANPC1ATMNAMPTSMN1; SMN2 | |
| SCHEMBL3711607 | 0.78 | NAMPT (0.80) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122924-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| EP-2640704-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012067963-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122924-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122924-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | POLB 913/4885RAB9A 2177/4885NPC1 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.