SCHEMBL3698359

SCHEMBL3698359

c1ccc(OCCCSc2nnnn2-c2ccccc2)cc1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 12/20 0.87
TSHR P16473 5/20 0.87
L3MBTL1 Q9Y468 4/20 0.87
SMN1; SMN2 Q16637 3/20 0.87
NPC1 O15118 2/20 0.87
NFKB1 P19838 2/20 0.87
RAB9A P51151 2/20 0.87
NFKB2 Q00653 2/20 0.87
RELA Q04206 2/20 0.87
TDP1 Q9NUW8 1/20 0.87
LMNA P02545 6/20 0.73
HPGD P15428 4/20 0.62
MAPK1 P28482 1/20 0.62
POLB P06746 3/20 0.57
NPSR1 Q6W5P4 1/20 0.57
THRB P10828 2/20 0.57
TP53 P04637 3/20 0.55
MAPT P10636 2/20 0.55
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10973042 0.87 ALDH1A1 (0.71) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL10970208 0.87 ALDH1A1 (0.71) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL7303919 0.84 ALDH1A1 (0.66) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL7301329 0.84 ALDH1A1 (0.66) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL16116944 0.81 ALDH1A1 (0.72) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL10972734 0.81 ALDH1A1 (0.63) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL16526226 0.80 ALDH1A1 (0.70) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL18686921 0.80 ALDH1A1 (0.72) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL6510534 0.79 ALDH1A1 (0.63) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1
SCHEMBL24305911 0.79 ALDH1A1 (0.68) ALDH1A1TSHRL3MBTL1SMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250099419-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2025-03-27 US disclosed
US-12201603-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2025-01-21 US disclosed
US-20230190698-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2023-06-22 US disclosed
US-11617733-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2023-04-04 US disclosed
US-20210169842-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2021-06-10 US disclosed
US-10940134-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2021-03-09 US disclosed
US-20200093781-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2020-03-26 US disclosed
US-20190111019-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2019-04-18 US disclosed
US-10201520-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2019-02-12 US disclosed
US-20180116995-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2018-05-03 US disclosed
EP-2653468-B1 Bicyclic Compound and Use Thereof for Medical Purposes ONO PHARMACEUTICAL CO (JP) 2016-02-24 EP disclosed
US-20150112079-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2015-04-23 US disclosed
US-8962868-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2015-02-24 US disclosed
EP-2460801-B1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO (JP) 2014-06-25 EP disclosed
CN-102498105-B Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICAL CO 2014-04-02 CN disclosed
US-20140073676-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2014-03-13 US disclosed
US-8614340-B2 Bicyclic compound and use thereof for medical purposes ONO PHARMACEUTICALS CO., LTD. (JP) 2013-12-24 US disclosed
EP-2653468-A1 Bicyclic Compound and Use Thereof for Medical Purposes ONO PHARMACEUTICAL CO., LTD. (JP) 2013-10-23 EP disclosed
EP-2460801-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO Pharmaceutical Co., Ltd. (JP) 2012-06-06 EP disclosed
US-20120122964-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES ONO PHARMACEUTICAL CO., LTD. (JP) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230190698-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20250099419-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20180116995-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20200093781-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-11617733-B2 Bicyclic compound and use thereof for medical purposes CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-10201520-B2 Bicyclic compound and use thereof for medical purposes CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20190111019-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-10940134-B2 Bicyclic compound and use thereof for medical purposes CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20210169842-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-12201603-B2 Bicyclic compound and use thereof for medical purposes CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20150112079-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20140073676-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885
US-20120122964-A1 BICYCLIC COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES CYP4A11, PDE3A, GUCY1B1 ALDH1A1 716/4885TSHR 3997/4885L3MBTL1 4263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.