Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31173835 | 0.87 | MAPKAPK2 (0.47) | NPC1MAPKAPK2MKNK1MKNK2 | |
| SCHEMBL17723760 | 0.87 | L3MBTL1 (0.54) | NPC1L3MBTL1KLKB1ACHE | |
| SCHEMBL2893669 | 0.87 | L3MBTL1 (0.40) | NPC1L3MBTL1KLKB1ACHEKLK1 | |
| SCHEMBL28769640 | 0.85 | L3MBTL1 (0.39) | NPC1L3MBTL1KLKB1ACHELMNA | |
| SCHEMBL18074418 | 0.84 | L3MBTL1 (0.41) | NPC1L3MBTL1KLKB1ACHELMNA | |
| SCHEMBL20271394 | 0.84 | HPGD (0.39) | NPC1L3MBTL1KLKB1ACHELMNA | |
| SCHEMBL31639060 | 0.83 | L3MBTL1 (0.37) | NPC1L3MBTL1KLKB1ACHELMNA | |
| SCHEMBL31196012 | 0.83 | KLKB1 (0.40) | NPC1L3MBTL1KLKB1ACHEKLK1 | |
| SCHEMBL27166661 | 0.83 | L3MBTL1 (0.37) | NPC1L3MBTL1KLKB1ACHEKLK1 | |
| SCHEMBL5928297 | 0.83 | MEN1 (0.39) | NPC1L3MBTL1KLKB1LMNADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168401-A1 | SULPHONAMIDE COMPOUNDS | Anaxis Pharma Pty Ltd (AU) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022268119-A1 | SULFOXIMINE COMPOUND AND USE THEREOF | 南京明德新药研发有限公司 | 2022-12-29 | — | — | WO | disclosed |
| CN-114685505-A | Imidazopyrrolopyridines as JAK family kinase inhibitors | 詹森药业有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-110312719-B | Imidazopyrrolopyridines as JAK family kinase inhibitors | 詹森药业有限公司 | 2022-04-15 | — | — | CN | disclosed |
| EP-2203429-A1 | PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS | Nissan Chemical Industries, Ltd. (JP) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009057827-A1 | PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2009-05-07 | — | — | WO | disclosed |