⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9387988 | 0.98 | ADH1C (0.48) | — | |
| SCHEMBL1246938 | 0.92 | — | — | |
| Glyoxylate SCHEMBL8522137 | 0.89 | HDAC2 (0.41) | — | |
| SCHEMBL1247085 | 0.81 | — | — | |
| Fosmidomycin SCHEMBL14485270 | 0.74 | S1PR2 (0.50) | — | |
| SCHEMBL97181 | 0.74 | ADH1C (0.48) | — | |
| SCHEMBL2361603 | 0.74 | ADH1C (0.48) | — | |
| SCHEMBL3962903 | 0.72 | ADH1C (0.52) | — | |
| SCHEMBL2007141 | 0.72 | — | — | |
| SCHEMBL95389 | 0.72 | ADH1C (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 217 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533979-B2 | Amino-derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2017-01-03 | — | — | US | claimed |
| JP-4789927-B2 | — | — | 2011-10-12 | — | — | JP | claimed |
| US-20110092447-A1 | USING INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF INHERITED DISEASE PREDISPOSING CONDITIONS | HENTSCH BERND | 2011-04-21 | — | — | US | claimed |
| US-7892833-B2 | Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions | TOPOTARGET GERMANY AG (DE) | 2011-02-22 | — | — | US | claimed |
| WO-2010123507-A1 | TREATMENT OF NON-LOCALIZED INFLAMMATION WITH PAN-HDAC INHIBITORS | PHARMACYCLICS, INC. (US) | 2010-10-28 | — | — | WO | claimed |
| EP-2001458-B1 | USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS | TOPOTARGET GERMANY AG (DE) | 2010-08-11 | — | — | EP | claimed |
| US-20090270497-A1 | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors | PHARMACYCLICS, INC. (US) | 2009-10-29 | — | — | US | claimed |
| US-20090186809-A1 | USE OF VALPROIC ACID FOR THE TOPICAL TREATMENT OF MILD TO MODERATE ACNE VULGARIS | TOPOTARGET GERMANY AG (DE) | 2009-07-23 | — | — | US | claimed |
| EP-2039355-A2 | Topical use of valproic acid for the prevention or treatment of skin disorders | TopoTarget Germany AG (DE) | 2009-03-25 | — | — | EP | claimed |
| US-20080318923-A1 | 1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2008-12-25 | — | — | US | claimed |
| US-20070037738-A1 | Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions | TOPOTARGET GERMANY AG (DE) | 2007-02-15 | — | — | US | claimed |
| WO-2007009539-A2 | USE OF INHIBITORS OF HISTONE DEACETYLASES IN COMBINATION WITH NSAID FOR THE THERAPY OF CANCER AND/OR INFLAMMATORY DISEASES | TOPOTARGET GERMANY AG (DE) | 2007-01-25 | — | — | WO | claimed |
| EP-1743654-A1 | Use of inhibitors of histone deacetylases in combination with NSAID for the therapy of cancer and/or inflammatory diseases | TopoTarget Germany AG (DE) | 2007-01-17 | — | — | EP | claimed |
| US-20060160897-A1 | Topical Use of Valproic Acid for the Prevention or Treatment of Skin Disorders | TOPOTARGET GERMANY AG (DE) | 2006-07-20 | — | — | US | claimed |
| EP-1635808-A1 | TOPICAL USE OF VALPROIC ACID FOR THE PREVENTION OR TREATMENT OF SKIN DISORDERS | TopoTarget Germany AG (DE) | 2006-03-22 | — | — | EP | claimed |
| EP-1635798-A2 | INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF DISEASES | TopoTarget Germany AG (DE) | 2006-03-22 | — | — | EP | claimed |
| WO-2005105055-A1 | FORMULATION COMPRISING HISTONE DEACETYLASE INHIBITORS | TOPOTARGET GERMANY AG (DE) | 2005-11-10 | — | — | WO | claimed |
| EP-1591109-A1 | Formulation comprising histone deacetylase inhibitor exhibiting biphasic release | G2M Cancer Drugs AG (DE) | 2005-11-02 | — | — | EP | claimed |
| WO-2005000282-A2 | INHIBITORS OF HISTONE DEACETYLASES FOR THE SUPPRESSION THERAPY OF DISEASES | TOPOTARGET GERMANY AG (DE) | 2005-01-06 | — | — | WO | claimed |
| WO-2005000289-A1 | TOPICAL USE OF VALPROIC ACID FOR THE PREVENTION OR TREATMENT OF SKIN DISORDERS | TOPOTARGET GERMANY AG (DE) | 2005-01-06 | — | — | WO | claimed |