Glyoxylate

Glyoxylate

SCHEMBL8522137

CCCCCN(O)C=O.O=CC(=O)O

nearest known ligand 0.49

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 5/20 0.41
HDAC8 Q9BY41 5/20 0.41
HDAC6 Q9UBN7 4/20 0.41
HDAC1 Q13547 3/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
ADH1C P00326 1/20 0.39
ADH1A P07327 1/20 0.39
ADH4 P08319 1/20 0.39
ZDHHC20 Q5W0Z9 1/20 0.38
PDF Q9HBH1 1/20 0.38
KDM5A P29375 1/20 0.38
KDM5C P41229 1/20 0.38
KDM4C Q9H3R0 1/20 0.38
KDM5B Q9UGL1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL369986 0.89
SCHEMBL9387988 0.87 ADH1C (0.48) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL1246938 0.83
Nonanol SCHEMBL27607030 0.74 TSHR (0.62) HDAC11
Butyl Alcohol SCHEMBL17722371 0.73 ALDH1A1 (0.58) HDAC11AKR1B1
SCHEMBL1247085 0.73
SCHEMBL6135712 0.72 HDAC2 (0.51) HDAC2HDAC8HDAC6HDAC1HDAC3
SCHEMBL4961171 0.71 ADH1C (0.41) HDAC11ADH1CADH1AADH4ZDHHC20
SCHEMBL16792232 0.70 CAMK2A (0.46) HDAC2HDAC8HDAC6HDAC1HDAC3
Glyoxylate SCHEMBL27518556 0.70 TSHR (0.55) HDAC11AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0953835-A1 Apparatus for detection of a fluorescence pattern corresponding to ligand binding on a substrate AFFYMAX TECHNOLOGIES N.V. (AN) 1999-11-03 EP disclosed
EP-0902034-A2 Very large scale immobilized peptide synthesis AFFYMAX TECHNOLOGIES N.V. (AN) 1999-03-17 EP disclosed
EP-0619321-B1 Method and apparatus for investigating polynucleotide or amino acid sequences AFFYMAX TECH NV (AN) 1999-01-07 EP disclosed
EP-0619321-A1 Very large scale immobilized peptide synthesis AFFYMAX TECHNOLOGIES N.V. (AN) 1994-10-12 EP disclosed
EP-0476014-B1 VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS AFFYMAX TECH NV (AN) 1994-08-31 EP disclosed
EP-0502060-A4 SPATIALLY-ADDRESSABLE IMMOBILIZATION OF ANTI-LIGANDS ON SURFACES 1993-05-05 EP disclosed
EP-0502060-A1 SPATIALLY-ADDRESSABLE IMMOBILIZATION OF ANTI-LIGANDS ON SURFACES AFFYMAX TECHNOLOGIES N.V. (AN) 1992-09-09 EP disclosed
EP-0476014-A1 VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS. AFFYMAX TECH NV (NL) 1992-03-25 EP disclosed
WO-1991007087-A1 SPATIALLY-ADDRESSABLE IMMOBILIZATION OF ANTI-LIGANDS ON SURFACES AFFYMAX TECHNOLOGIES N.V. (AN) 1991-05-30 WO disclosed
WO-1990015070-A1 VERY LARGE SCALE IMMOBILIZED PEPTIDE SYNTHESIS AFFYMAX TECHNOLOGIES N.V. (AN) 1990-12-13 WO disclosed