Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.35 |
| ▸ | TNF | P01375 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL701250 | 0.88 | KMO (0.39) | PTGDR2POLBDHODHPTGDR | |
| SCHEMBL733809 | 0.87 | PTGDR2 (0.42) | PTGDR2DHODHPTGDRATM | |
| SCHEMBL733257 | 0.86 | CYP11B1 (0.41) | SMN1; SMN2NOD1TNFPTGDR2DHODH | |
| SCHEMBL732680 | 0.84 | GAA (0.35) | GAAKMT2ASMN1; SMN2NOD1TNF | |
| SCHEMBL732679 | 0.84 | GAA (0.35) | GAAKMT2ASMN1; SMN2NOD1TNF | |
| SCHEMBL732108 | 0.82 | KDM4C (0.41) | PTGDR2 | |
| SCHEMBL732107 | 0.82 | KDM4C (0.41) | PTGDR2 | |
| SCHEMBL3690025 | 0.81 | DHODH (0.37) | KMT2ANOD1TNFRAB9ADHODH | |
| SCHEMBL3690030 | 0.81 | DHODH (0.37) | KMT2ANOD1TNFRAB9ADHODH | |
| SCHEMBL733721 | 0.81 | MMP2 (0.43) | KMT2ANOD1TNFNOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307383-B1 | AMINOTETRAHYDROINDAZOLOACETIC ACIDS | HOFFMANN LA ROCHE (CH) | 2012-05-16 | — | — | EP | claimed |