Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 1.00 |
| ▸ | MMEL1 | Q495T6 | 4/20 | 1.00 |
| ▸ | ACE | P12821 | 5/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709244 | 1.00 | MME (1.00) | MMEMMEL1ACE | |
| SCHEMBL14890350 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| SCHEMBL3714794 | 0.89 | MME (0.80) | MMEMMEL1ACE | |
| SCHEMBL3710898 | 0.89 | MME (0.80) | MMEMMEL1ACE | |
| Lbq-657 SCHEMBL391633 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| Lbq-657 SCHEMBL489122 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| Lbq-657 SCHEMBL7433849 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| Lbq-657 SCHEMBL9565416 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| Lbq-657 SCHEMBL1908575 | 0.89 | MME (1.00) | MMEMMEL1ACE | |
| SCHEMBL2878447 | 0.86 | MME (1.00) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673974-B2 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2014-03-18 | — | — | US | disclosed |
| US-8673974-B2 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2014-03-18 | — | — | US | disclosed |
| US-8673974-B2 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2014-03-18 | — | — | US | disclosed |
| EP-2640690-A1 | SUBSTITUTED AMINO BISPHENYL PENTANOIC ACID DERIVATIVES AS NEP INHIBITORS | Novartis AG (CH) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012065956-A1 | SUBSTITUTED AMINO BISPHENYL PENTANOIC ACID DERIVATIVES AS NEP INHIBITORS | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012065956-A1 | SUBSTITUTED AMINO BISPHENYL PENTANOIC ACID DERIVATIVES AS NEP INHIBITORS | NOVARTIS AG (CH) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | NOVARTIS AG (CH) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122977-A1 | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors | REN, MME, AGTR1 | MME 2/4885MMEL1 545/4885ACE 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.