SCHEMBL3700629

SCHEMBL3700629

Nc1ccc(-c2ccc(N)c([N+](=O)[O-])c2[N+](=O)[O-])c([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
USP2 O75604 1/20 0.47
KEAP1 Q14145 1/20 0.47
NFE2L2 Q16236 1/20 0.47
ALDH1A1 P00352 5/20 0.44
TDP1 Q9NUW8 6/20 0.43
CYP3A4 P08684 3/20 0.43
MAPT P10636 3/20 0.43
POLB P06746 1/20 0.43
ALOX15 P16050 1/20 0.43
TSHR P16473 3/20 0.41
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
LMNA P02545 2/20 0.39
RAB9A P51151 1/20 0.39
TLR9 Q9NR96 1/20 0.39
PTPRC P08575 1/20 0.39
S100A4 P26447 1/20 0.39
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27832802 0.90 MEN1 (0.53) MEN1KMT2AUSP2KEAP1NFE2L2
Hydrazine SCHEMBL5753983 0.85 ALDH1A1 (0.44) MEN1KMT2AALDH1A1TDP1CYP3A4
SCHEMBL9060381 0.84 ALDH1A1 (0.48) MEN1KMT2AUSP2KEAP1NFE2L2
SCHEMBL153658 0.84 ALDH1A1 (0.50) MEN1KMT2AUSP2KEAP1NFE2L2
Hydrazine SCHEMBL27667270 0.82 ALDH1A1 (0.42) MEN1KMT2AALDH1A1TDP1CYP3A4
SCHEMBL304540 0.79 TDP1 (0.52) MEN1KMT2AUSP2KEAP1NFE2L2
SCHEMBL29209663 0.78 ALDH1A1 (0.51) MEN1KMT2AUSP2KEAP1NFE2L2
SCHEMBL30488438 0.78 MEN1 (0.48) MEN1KMT2AUSP2KEAP1NFE2L2
SCHEMBL6048769 0.78 MEN1 (0.48) MEN1KMT2AUSP2KEAP1NFE2L2
SCHEMBL12170111 0.78 MEN1 (0.48) MEN1KMT2AUSP2KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150079587-A1 METHOD FOR DETECTING NUCLEIC ACIDS BY SIMULTANEOUS ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND SIGNAL PROBE GREEN CROSS MEDICAL SCIENCE CORP. (KR) 2015-03-19 US disclosed
CN-1798976-B Method of diagnosis of foot and mouth disease and the diagnostic kit REP KOREA NAT VET & QUARANTINE 2011-03-23 CN disclosed
US-20100311058-A1 METHOD FOR DETECTING NUCLEIC ACIDS BY SIMULTANEOUS ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND SIGNAL PROBE RAPLEGENE INC. (KR) 2010-12-09 US disclosed
WO-2009072705-A1 METHOD FOR DETECTING NUCLEIC ACIDS BY SIMULTANEOUS ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND SIGNAL PROBE RAPLEGENE INC. (KR) 2009-06-11 WO disclosed
US-20090130677-A1 METHOD FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND METHOD FOR DETECTING NUCLEIC ACIDS USING SIMULTANEOUS ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND SIGNAL PROBE GREEN CROSS MEDICAL SCIENCE CORP. (KR) 2009-05-21 US disclosed
US-20070128587-A1 Method of diagnosis of foot and mouth disease and the diagnostic kit Republic of Korea ( National Veterinary Research and Quarantine Service) (KR) 2007-06-07 US disclosed
WO-2007043751-A1 METHOD FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND METHOD FOR DETECTING NUCLEIC ACIDS USING SIMULTANEOUS ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS AND SIGNAL PROBE RAPLEGENE INC. (KR) 2007-04-19 WO disclosed
EP-1618381-A4 METHOD OF DIAGNOSIS OF FOOT AND MOUTH DISEASE AND THE DIAGNOSTIC KIT REP KOREA NAT VET & QUARANTINE (KR) 2007-02-21 EP disclosed
CN-1798976-A Method of diagnosis of foot and mouth disease and the diagnostic kit REP KOREA NAT VET & QUARANTINE (KR) 2006-07-05 CN disclosed
EP-1618381-A1 METHOD OF DIAGNOSIS OF FOOT AND MOUTH DISEASE AND THE DIAGNOSTIC KIT Republic of Korea (National Veterinary Research and Quarantine Service) (KR) 2006-01-25 EP disclosed
WO-2004097418-A1 METHOD OF DIAGNOSIS OF FOOT AND MOUTH DISEASE AND THE DIAGNOSTIC KIT REPUBLIC OF KOREA (NATIONAL VETERINARY RESEARCH AND QUARANTINE SERVICE) (KR) 2004-11-11 WO disclosed
US-4935544-A Polynitrobiphenyl derivative THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1990-06-19 US disclosed
US-4935544-A Polynitrobiphenyl derivative THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1990-06-19 US disclosed