Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.41 |
| ▸ | RXRB | P28702 | 3/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709692 | 0.92 | MAPT (0.44) | NR1H4GAARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3709661 | 0.84 | LPAR1 (0.41) | NR1H4LPAR1SRD5A2POLBSMN1; SMN2 | |
| SCHEMBL2335539 | 0.83 | LPAR1 (0.45) | NR1H4GAARXRARXRBLPAR1 | |
| SCHEMBL3702204 | 0.82 | TP53 (0.38) | LPAR1RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3712524 | 0.82 | LPAR1 (0.42) | GAARXRARXRBLPAR1POLB | |
| SCHEMBL3702563 | 0.82 | NR1H4 (0.46) | NR1H4ALOX5ALOX5APLPAR1 | |
| SCHEMBL2335475 | 0.82 | KDM4E (0.39) | LPAR1RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3701994 | 0.81 | NR1H4 (0.46) | NR1H4NR4A2NR4A1NR4A3RAB9A | |
| SCHEMBL3715778 | 0.80 | KDM4E (0.38) | LPAR1RAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3702315 | 0.80 | LPAR1 (0.40) | GAARXRARXRBLPAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |