Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 7/20 | 0.46 |
| ▸ | LIFR | P42702 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710883 | 0.92 | NR1H4 (0.48) | NR1H4LIFRMRGPRX4SMPD1LMNA | |
| SCHEMBL3706744 | 0.88 | IP6K1 (0.43) | NR1H4NPC1RAB9AMRGPRX4LMNA | |
| SCHEMBL2336147 | 0.88 | NR1H4 (0.42) | NR1H4LIFRMRGPRX4LMNA | |
| SCHEMBL1245111 | 0.87 | NR1H4 (0.50) | NR1H4LIFRNR4A2NPC1RAB9A | |
| SCHEMBL3702563 | 0.86 | NR1H4 (0.46) | NR1H4 | |
| SCHEMBL3714244 | 0.85 | KMO (0.41) | NR1H4HPGD | |
| SCHEMBL3708502 | 0.85 | IP6K1 (0.40) | NR1H4LIFRNPC1RAB9A | |
| SCHEMBL2335317 | 0.85 | LPAR1 (0.38) | NR1H4NPC1RAB9ALMNAHPGD | |
| SCHEMBL3706639 | 0.84 | IP6K1 (0.41) | NPC1RAB9ALMNAHPGD | |
| SCHEMBL3708634 | 0.83 | ALDH1A1 (0.42) | NR1H4NPC1RAB9ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | claimed |
| WO-2010077882-A2 | ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |