Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 17/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | MC4R | P32245 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salmefamol SCHEMBL2221384 | 0.92 | ADRB2 (0.68) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| Fenoterol SCHEMBL9791330 | 0.89 | ADRB2 (0.82) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| Albuterol SCHEMBL9238360 | 0.87 | ADRB2 (0.75) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| Levosalbutamol SCHEMBL18527021 | 0.87 | ADRB2 (0.75) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| Albuterol SCHEMBL328959 | 0.86 | ADRB2 (0.87) | ADRB2CYP3A4CYP2D6TSHRHIF1A | |
| Fenoterol SCHEMBL3793462 | 0.85 | ADRB2 (0.77) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| SCHEMBL11174404 | 0.83 | ADRB2 (0.61) | ADRB2CYP3A4MAPK1CYP2D6TSHR | |
| Albuterol SCHEMBL2489838 | 0.80 | ADRB2 (1.00) | ADRB2CYP2D6TSHRHIF1AADRB1 | |
| Levosalbutamol SCHEMBL4003 | 0.80 | ADRB2 (1.00) | ADRB2CYP2D6TSHRHIF1AADRB1 | |
| Fenoterol SCHEMBL5009 | 0.80 | ADRB2 (1.00) | ADRB2CYP3A4MAPK1CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010099523-A1 | METHOD OF TREATING REACTIVE AIRWAY DISEASE | UNIVERSITY OF CINCINNATI (US) | 2010-09-02 | — | — | WO | disclosed |