Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30991570 | 1.00 | AKT1 (0.56) | AKT1MAPTNPC1RAB9APKM | |
| Carbamic Acid SCHEMBL5329076 | 0.91 | AKT1 (0.49) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL2856886 | 0.86 | AKT1 (0.43) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL3047236 | 0.81 | AKT1 (0.44) | AKT1MAPTNPC1RAB9AGAA | |
| SCHEMBL6849624 | 0.80 | PKM (0.49) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL8894557 | 0.79 | MAPT (0.47) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL6025550 | 0.79 | PKM (0.48) | MAPTNPC1RAB9APKMKCNH2 | |
| SCHEMBL3042985 | 0.79 | MAPT (0.47) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL30513267 | 0.79 | AKT1 (0.56) | AKT1MAPTNPC1RAB9APKM | |
| SCHEMBL669764 | 0.79 | MAPT (0.47) | AKT1MAPTNPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8551981-B2 | Furo[3,2-d]pyrimidine compounds | ABBVIE INC. (US) | 2013-10-08 | — | — | US | disclosed |
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
| US-7683189-B2 | Process for producing aminobenzopyran compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
| US-7683189-B2 | Process for producing aminobenzopyran compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2010-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | CDK2, DPYD, CDK3 | AKT1 157/4885MAPT 2194/4885NPC1 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.