Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | BRD1 | O95696 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | SI | P14410 | 3/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12036000 | 0.81 | MAPT (0.40) | MAPTGAA | |
| SCHEMBL6849624 | 0.80 | PKM (0.49) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL30991570 | 0.79 | AKT1 (0.56) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL30888534 | 0.79 | MAPT (0.47) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL3701015 | 0.79 | AKT1 (0.56) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL3184205 | 0.79 | AKT1 (0.56) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL8894557 | 0.79 | MAPT (0.47) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL6025550 | 0.79 | PKM (0.48) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL669764 | 0.79 | MAPT (0.47) | MAPTNPC1RAB9APKMKDM1A | |
| SCHEMBL27634797 | 0.78 | KDM1A (0.52) | MAPTNPC1RAB9APKMKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142493-B1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERISATION | CENTRE NAT RECH SCIENT (FR) | 2019-03-27 | — | — | EP | disclosed |
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| US-8273768-B2 | Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-09-25 | — | — | US | disclosed |
| US-20100129471-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2010-05-27 | — | — | US | disclosed |
| EP-2142493-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERISATION | Centre National de la Recherche Scientifique (CNRS) (FR) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008122620-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERISATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-10-16 | — | — | WO | disclosed |
| CN-1150425-A | Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants | AMERICAN HOME PROD (US) | 1997-05-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100129471-A1 | ISO CA-4 AND ANALOGUES THEREOF AS POTENT CYTOTOXIC AGENTS INHIBITING TUBULINE POLYMERIZATION | TUBB4A, TUBA4A, TUBB4B | MAPT 81/4885NPC1 1704/4885RAB9A 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.