Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.41 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701397 | 1.00 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3R1EIF4A3 | |
| SCHEMBL3077903 | 0.83 | NPC1 (0.47) | PIK3CAPIK3CDPIK3CBEIF4A3TGFBR1 | |
| SCHEMBL3687917 | 0.80 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL3687915 | 0.80 | PIK3CD (0.52) | PIK3CAPIK3CDPIK3CBPIK3R1 | |
| SCHEMBL17067855 | 0.77 | TGFBR1 (0.49) | PIK3CAPIK3CDPIK3CBEIF4A3TGFBR1 | |
| SCHEMBL3089211 | 0.75 | EIF4A3 (0.45) | PIK3CAPIK3CDPIK3CBEIF4A3TGFBR1 | |
| SCHEMBL31030385 | 0.74 | EIF4A3 (0.47) | PIK3CAPIK3CDPIK3CBEIF4A3TGFBR1 | |
| SCHEMBL25158912 | 0.73 | ALDH1A1 (0.45) | PIK3CAPIK3CDPIK3CBPIK3R1EIF4A3 | |
| SCHEMBL25336177 | 0.73 | EPHB3 (0.44) | PIK3CAPIK3CDPIK3CBEIF4A3KDM4E | |
| SCHEMBL3077855 | 0.73 | EPHB3 (0.45) | PIK3CAPIK3CDPIK3CBEIF4A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074586-A1 | PYRAZOLO[1,5-A]PYRIDINE AND IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE IN CANCER THERAPY | PATHWAY THERAPEUTICS LIMITED (NZ) | 2010-07-01 | — | — | WO | disclosed |