Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3691481 | 0.97 | HRH3 (0.38) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Bromide SCHEMBL3699409 | 0.97 | HRH3 (0.38) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Hydrochloric Acid SCHEMBL3694712 | 0.97 | LMNA (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| SCHEMBL3693124 | 0.97 | HRH3 (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Hydrochloric Acid SCHEMBL3691911 | 0.94 | LMNA (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Hydrochloric Acid SCHEMBL3689397 | 0.94 | LMNA (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Bromide SCHEMBL3697257 | 0.90 | NR4A1 (0.45) | ALDH1A1LMNAMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL3694515 | 0.89 | L3MBTL1 (0.40) | HRH3HRH1ALDH1A1LMNATAAR1 | |
| Bromide SCHEMBL3686605 | 0.87 | NR4A1 (0.45) | ALDH1A1LMNAMAPTSMN1; SMN2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL3699077 | 0.87 | NR4A1 (0.45) | ALDH1A1LMNAMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741240-B2 | Transition metal compounds for olefin polymerization and oligomerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20080033125-A1 | Transition Metal Compounds for Olefin Polymerization and Oligomerization | EXXONMOBIL CHEMICAL PATENTS INC. | 2008-02-07 | — | — | US | disclosed |