Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21201593 | 0.84 | MAPT (0.61) | TP53MAPTMEN1KMT2APOLB | |
| SCHEMBL1346298 | 0.82 | MAPK14 (0.58) | TP53MAPTMEN1KMT2APOLB | |
| SCHEMBL27383592 | 0.82 | KMT2A (0.44) | KLKB1TP53MAPTKMT2APOLB | |
| SCHEMBL21419979 | 0.81 | MAPT (0.49) | TP53MAPTMEN1KMT2APOLB | |
| SCHEMBL29348734 | 0.80 | ACHE (0.48) | TP53MAPTKMT2APOLBMAPK14 | |
| SCHEMBL2552042 | 0.79 | MAPT (0.44) | KLKB1TP53MAPTMEN1KMT2A | |
| SCHEMBL4591705 | 0.77 | KDM4E (0.56) | MAPTMEN1KMT2APOLBKDM4E | |
| SCHEMBL25852695 | 0.77 | MAPT (0.43) | TP53MAPTMEN1KMT2APOLB | |
| SCHEMBL21201592 | 0.77 | MAPT (0.45) | TP53MAPTPOLBKEAP1NFE2L2 | |
| SCHEMBL4280056 | 0.76 | MAPT (0.43) | TP53MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268625-B1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | Bayer Pharma AG (DE) | 2012-05-16 | — | — | EP | disclosed |