Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1346298 | 0.83 | MAPK14 (0.58) | MAPTTP53MAPK14POLBKDM4E | |
| SCHEMBL25852695 | 0.81 | MAPT (0.43) | MAPTTP53MAPK14POLBKDM4E | |
| SCHEMBL29348734 | 0.80 | ACHE (0.48) | MAPTTP53MAPK14POLBKMT2A | |
| SCHEMBL27383591 | 0.80 | IDH1 (0.51) | MAPTTP53KDM4EMEN1KMT2A | |
| SCHEMBL27383784 | 0.78 | POLB (0.59) | MAPTTP53MAPK14POLBKDM4E | |
| SCHEMBL25852518 | 0.77 | MAPT (0.43) | MAPTTP53MAPK14POLBHTT | |
| SCHEMBL2552042 | 0.76 | MAPT (0.44) | MAPTTP53MAPK14POLBKDM4E | |
| SCHEMBL3702168 | 0.76 | KLKB1 (0.44) | MAPTTP53MAPK14POLBKDM4E | |
| SCHEMBL27383592 | 0.76 | KMT2A (0.44) | MAPTTP53MAPK14POLBKMT2A | |
| SCHEMBL25857996 | 0.74 | MAPT (0.42) | MAPTTP53MAPK14POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009127338-A1 | OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-10-22 | — | — | WO | disclosed |