Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 6/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28948917 | 1.00 | KMT2A (0.43) | KMT2ACA12CA14CA1CA2 | |
| SCHEMBL30539270 | 0.89 | CYP1A2 (0.50) | KMT2ACA1CA2CA7CTSK | |
| SCHEMBL1341495 | 0.88 | CYP1A2 (0.46) | CA12CA14CA1CA2CA7 | |
| SCHEMBL3819517 | 0.88 | CYP1A2 (0.46) | CA12CA14CA1CA2CA7 | |
| SCHEMBL295886 | 0.88 | CYP1A2 (0.46) | CA12CA14CA1CA2CA7 | |
| SCHEMBL2555252 | 0.87 | KMT2A (0.44) | KMT2ACA12CA14CA1CA2 | |
| SCHEMBL12555978 | 0.87 | KMT2A (0.44) | KMT2ACA12CA14CA1CA2 | |
| SCHEMBL800751 | 0.87 | KMT2A (0.44) | KMT2ACA12CA14CA1CA2 | |
| SCHEMBL18220550 | 0.87 | KMT2A (0.44) | KMT2ACA12CA14CA1CA2 | |
| SCHEMBL29604456 | 0.87 | ACE (0.54) | KMT2ACA1CA2CA7CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116396353-A | Method for realizing trifluoromethylation of cysteine and polypeptide containing cysteine residue by utilizing micro-flow field reaction device | 南京工业大学 | 2023-07-07 | — | — | CN | disclosed |
| CN-115108953-B | Sulfhydrylation of alkynylamides and selective modification of polypeptide cysteines | 江西师范大学 | 2023-06-02 | — | — | CN | disclosed |
| CN-115108953-A | Thiohydrogenation of alkynylamides and selective modification of polypeptide cysteines | 江西师范大学 | 2022-09-27 | — | — | CN | disclosed |
| CN-114573658-A | Method for realizing pyridine selective functionalization of cysteine and polypeptide thereof by using microchannel reactor | 南京工业大学 | 2022-06-03 | — | — | CN | disclosed |
| US-20160326212-A1 | Chemical Modification of Proteins | R.P. SCHERER TECHNOLOGIES, LLC | 2016-11-10 | — | — | US | disclosed |
| US-9346851-B2 | Chemical modification of proteins | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2016-05-24 | — | — | US | disclosed |
| EP-2254900-B1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS INNOVATION (GB) | 2012-03-14 | — | — | EP | disclosed |
| US-20110144304-A1 | Chemical Modification of Proteins | REDWOOD BIOSCIENCE, INC. | 2011-06-16 | — | — | US | disclosed |
| WO-2009103941-A1 | CHEMICAL MODIFICATION OF PROTEINS | ISIS INNOVATION LIMITED (GB) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144304-A1 | Chemical Modification of Proteins | SCLY, PTMS, QPCT | KMT2A 2362/4885CA12 2552/4885CA14 3121/4885 |
| US-20160326212-A1 | Chemical Modification of Proteins | SCLY, PTMS, QPCT | KMT2A 2362/4885CA12 2552/4885CA14 3121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.