SCHEMBL3703552

SCHEMBL3703552

CCOC(=O)c1c(C)nc(-c2ccccc2)c(C(=O)OCC)c1C#Cc1ccccc1

nearest known ligand 0.87

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 13/20 0.87
ALDH1A1 P00352 5/20 0.56
KDM4E B2RXH2 3/20 0.56
LMNA P02545 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
MAPT P10636 2/20 0.56
RAB9A P51151 2/20 0.56
NPC1 O15118 2/20 0.56
GAA P10253 1/20 0.56
HPGD P15428 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
TP53 P04637 1/20 0.51
HSD17B10 Q99714 1/20 0.51
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.49
TSHR P16473 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7678825 0.78 ADORA3 (1.00) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL13780197 0.78 ADORA3 (0.74) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL7686715 0.76 ADORA3 (0.90) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL7685833 0.76 ADORA3 (0.76) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL7686721 0.75 ADORA3 (1.00) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL10377778 0.75 ADORA3 (0.62) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL7678610 0.74 ADORA3 (0.68) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL27708854 0.73 ADORA3 (0.67) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL28199488 0.73 ADORA3 (0.76) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2
SCHEMBL10375625 0.73 KDM4E (0.60) ADORA3ALDH1A1KDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885192-B8 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) 2012-05-16 EP disclosed
EP-0885192-A1 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN- ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVE, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1998-12-23 EP disclosed
WO-1997027177-A2 DIHYDROPYRIDINE-, PYRIDINE-, BENZOPYRAN-4-ONE- AND TRIAZOLOQUINAZOLINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-07-31 WO disclosed